@import url('https://fonts.googleapis.com/css2?family=Ubuntu:ital,wght@0,300;0,400;0,500;0,700;1,300;1,400;1,500;1,700&display=swap');
body {
	font-family: 'Ubuntu', sans-serif;
	padding-top: 87px!important;
}
body.fr{
	padding-top: 98.625px!important;
}
h1,
h2,
h3,
h4,
h5 {
	
}
.fr .patient-support-program-logo img {
    width: 25%;
}
h1{
	color: #003a5d;
    font-weight: 700;
	font-size:40px;
}
h2{
	color:#003A5D;  
	margin-bottom: 2.5rem;
	font-size: 2.25rem;
}
h3{
	color:#003A5D;
}
h4{
	color:#003A5D;
	font-weight:400;
}
h5 {
	color:#003A5D;
	font-weight:500;
}
p {
	color: #003A5D;
	font-size:18px;
	line-height:1.6;
}
ul li{
	font-size:18px;
}
p a{
	color: #003A5D;
}
img {
	max-width: 100%;
}
sup {
	font-size: 65%;
}
h2 sup {
	font-size: 65%;
    top: -0.4em;
}

a.main-content:focus-within {
    color: #000;
    border: 3px solid #f89a1c;
    top: 0;
    z-index: 1031;
	background-color: #fff;
}

.text-block h4 {
    color: #003A5D;
    font-weight: 400;
    font-size: 1.5rem;
}
a.btn.btn-default.btn-learn-more:hover {
    border: 1px solid #81470E;
}
#modal-content:focus-visible{
	border: 2px solid #f89a1c;
}
#modal-content1:focus-visible{
	border: 2px solid #f89a1c;
}
a.navbar-brand {
    border: 2px solid transparent;
}
.navbar.navbar-expand-lg a.navbar-brand {
    width: 150px;
}
a.nav-link {
    border: 2px solid transparent;
}
a.btn.btn-default.btn-learn-more {
    border: 2px solid transparent;
    font-size: 15px;
}
.footenote-section a.study-design-anchor {
    margin-bottom: 1rem;
    color: #753900!important;
    font-size: 18px;
    font-weight: 800;
}
ul.footer-part-menus {
    display: flex;
    padding-left: 0;
    list-style: none;
}
ul.footer-part-menus li a {
    color: #003A5D;
    font-size: 12px;
}
ul.footer-part-menus li span {
    font-size: 12px;
}
.patient-support-program-logo img {
    width: 125px;
}
.fr .patient-support-program-block-text {
   
    left: 10rem;
    top: 17px;
}

section#section1 h1.mb-4 {
    color: #003A5D;
    font-weight: 400;
    font-size: 1.5rem;
}
section.pde4-section h1 {
    color: #003A5D;
    margin-bottom: 2.5rem;
    font-size: 2.25rem;
    font-weight: 500;
    line-height: 1.2;
}
.pde4-section h2 {
    margin-bottom: 4rem;
    color: #003A5D;
    font-size: 24px;
    font-weight: 700;
    margin-top: 5rem;
}
.pharmacology .pde4-section h2{
	margin-top: 2rem;
	margin-bottom: 2rem;
}
.pharmacology .pde4-section .pdeaction {
    font-size: 2.25rem;
}
.text-block h3 {
    color: #003A5D;
    font-weight: 400;
    font-size: 1.5rem;
}
.col-sm-11.mx-auto h1.mb-5 {
    color: #003A5D;
    font-size: 24px;
}
img[alt*="arrow-right"] {
    width: 22px;
    height: 73px;
}
h2.isi-sub-heading {
    font-size: 16px;
    font-weight: 700;
    line-height: 1.5;
    text-decoration: underline;
}
h3.isi-sub-heading-second {
    font-size: 16px;
    font-weight: 700;
    line-height: 1.5;
}
section#otezla-program {
    padding-bottom: 3rem;
}
#otezla-program h2.otezla-program-heading {
    color: #003A5D;
    margin-bottom: 2.5rem;
    font-size: 2.25rem;
    font-weight: 500;
	margin-top: 0;
}
#otezla-program h2 {
    margin-bottom: 1rem;
    margin-top: 2rem;
}
#otezla-program a {
    text-decoration: underline;
}
#otezla-program .footnote p {
    font-size: 12px;
    padding-top: 1rem;
}
.ez-start-patient-support-program h2 {
    font-size: 24px;
    font-weight: 700;
}
.services-section h2{
	font-size: 1.5rem;
}
.services-section .text-block h3 {
    color: #003A5D;
    font-size: 18px;
    line-height: 1.6;
    font-weight: 700;
}
.behcets-disease .content.otezla-first-only h1{
		padding-bottom: 8rem;
    font-weight: 700;
    font-size: 1.5rem!important;
    margin-bottom: 0.5rem;
   
    line-height: 1.2;
	}
.p-relative{
	position:relative;
}
.index .content {
	background-image: linear-gradient(#2AADEC, #FAFAF8);
	background-image: url(../images/banner-img-login.png);
}
.content {
    padding-right: 15px;
    padding-left: 15px;
    margin-right: auto;
    margin-left: auto;
}
.btn-default{
	color: #fff;
    background-color: #B85C00;
    display: flex;
    align-items: center;
    justify-content: center;
	font-weight: 600;
}

a.btn.btn-default.format-change:hover {
    color: #425563;
    background-color: #fff;
    border: 1px solid #425563;
}
.brown-box.text-center p.mb-0 {
    color: #713D09;
}
#welcome-modal .btn-default {
    font-weight: 500;
}
.disease-areas .btn-default {
    font-weight: 500;
}
.form-control:focus {
    box-shadow: none;
	border-color: #6E6E6E;
}
.btn-default:hover{
	color: #fff;
    background-color: #E88320;
}
.btn-register{
	/* margin-top:1rem; */
    max-width: 97px;
	font-weight: 500;
}
.btn-register:hover{
	color: #E88320;
    background-color: #fff;
	border: 1px solid #E88320;
}
.btn-learn-more{
    max-width: 133px;
}
.btn-learn-more:hover, .btn-default:hover{
	color: #81470E;
    background-color: #fff;
    border: 1px solid #81470E;
}
.footenote-section p{
	font-size: 12px;
    text-indent: -8px;
    margin-left: 10px;
    color: #2c2c2c;
    margin-bottom: 0px;
	line-height:1.3;
}
.disease-areas-efficacy-profile .footenote-section p, .disease-areas .footenote-section p, .pharmacology .footenote-section p, .psoriatic-arthritis-efficacy .footenote-section p, .psoriasis-efficacy .footenote-section p, .psa-safety-profile .footenote-section p, .behcets-disease-efficacy .footenote-section p, .behcets-disease-efficacy .footenote-section p, .our-experience .footenote-section p, .pso-safety-profile .footenote-section p, .ez-start-bridging-program-app .footenote-section p{
	color:#2C2C2C;
}
.index label{
	color:#2C2C2C;
	margin-bottom: .25rem;
	font-size: 14px;
}
.index-heading{
	margin-top: 2rem;
    margin-bottom: 2rem;
    font-size: 1.25rem;
}
.form-control {
    border: 1.5px solid #6E6E6E;
	max-height: 36px;
}
.index-banner{
	height: 100%;
    min-height: 816px;
	display: flex;
    align-items: center;
    justify-content: center;
}
.index-banner-content {
	text-align:center;
}
.index-banner-content h1{
	margin-bottom: 4rem;
    max-width: 645px;
	line-height: 1.25;
	font-size: 40px;
	color: #002b42;
}
.index-content-logo{

}
.warning-text{
	color: #A30000;
    visibility: hidden;
    margin-bottom: 0px;
    font-size: 13px;
}
.banner{
	/* background-image: linear-gradient(180deg, #2AADEC 0%, #F4F5F6 45%); */
	background-image: url(../images/banner-img-new.png);
    height: 100%;
    min-height: 400px;
    display: flex;
    align-items: center;
    justify-content: center;
	margin-left: -15px;
    margin-right: -15px;
	padding-top: 2rem;
    padding-bottom: 2rem;
	background-repeat: no-repeat;
    background-size: contain;
}
.home .banner {
    /* background-image: linear-gradient(180deg, #2AADEC 0%, #FFFFFF 40%); */
	background-image: url(../images/banner-img-new.png);
}
.behcets-disease .banner {
	background-size: cover;
	background-position: bottom;
}
.card-blocks{
	margin-top:2rem;
	margin-bottom:7rem;
}
.pharmacology .pde4-section .card-blocks h3{
	font-weight: 500;
}
.pharmacology .pde4-section .card-blocks .text-block h3{
	font-size: 28px;
}
.card-blocks .btn-default {
    display: inline-block;
}
.home .card-block{
	text-align: center;
    max-width: 265px;
    margin: 0 auto;
}
.home .card-blocks{
	margin-bottom: 4rem;
}
.home .brown-box-section {
    margin-bottom: 4rem;
}
.home .footenote-section {
    padding-bottom: 2rem;
}
.card-block h5{
    margin-top: 1.5rem;
    margin-bottom: 1.5rem;
    font-size: 24px;
}
.card-block h2{
    margin-top: 1.5rem;
    margin-bottom: 1.5rem;
    font-size: 24px;
}
.card-block .btn{
	margin: 0 auto;
}
.card-block img{
	border-radius:50%;
}
.brown-box-section{
	margin-bottom:9rem;
}
.get-started .brown-box-section {
    margin-bottom: 4rem;
}
.get-started .footenote-section {
    padding-bottom: 4rem;
}
.pasi-75-response-section .brown-box {
	margin-bottom: 1rem;
}
.pruritus-response-section .brown-box {
	margin-bottom: 1rem;
}
.pruritus-response-section .footenote-section:last-of-type {
	padding-bottom: 8rem;
}
.actual-patient-results .footenote-section {
    padding-bottom: 7rem;
    padding-top: 2rem;
}

.pde4-section .brown-box-section, .change-in-the-number-of-oral-ulcers-section .brown-box-section, .esteem-safety-data-section .brown-box-section{
	margin-bottom:4rem;
}
.brown-box{
	background-color:#FFE8CC;
	padding-top:1rem;
	padding-bottom:1rem;
	display:flex;
	align-items:center;
	border-top: 5px solid #e88320;
	justify-content:center;
}
.psoriatic-arthritis-efficacy .brown-box,  .pasi-75-response-section .brown-box, .pruritus-response-section .brown-box, .psa-safety-profile .brown-box, .behcets-disease-efficacy .brown-box, .behcets-disease-safety-profile .brown-box, .pso-safety-profile .brown-box, .ez-start-bridging-program-app .brown-box, .ez-start-patient-support-program .brown-box{
	justify-content: start;
    padding-left: 3rem;
    padding-right: 3rem;
}
.psoriatic-arthritis-efficacy .brown-box-section{
    margin-bottom: 5rem;
}
.brown-box.bb-with-img{
	padding-left: 0rem;
}
.actual-patient-results .brown-box-section{
    padding-top: 2rem;
	margin-bottom: 3rem;
}
.actual-patient-results .brown-box{
	justify-content: start;
    padding-left: 3rem;
}
.actual-patient-results h1 sup {
    font-size: 65%;
    top: -0.4em;
}
.brown-box img{
	float:left;
	margin-right: 25px;
    margin-left: 25px;
}
.brown-box p{
	font-weight: 500;
    font-size: 20px;
    color: #75400B;
}
.psa-safety-profile .brown-box p, .behcets-disease-efficacy .brown-box p, .behcets-disease-safety-profile p{
	font-weight: 400;
	line-height: 1.3;
}
.ez-start-bridging-program-app .brown-box p, .actual-patient-results .brown-box p, .psoriasis-efficacy .brown-box p, .pharmacology .brown-box p, .ez-start-patient-support-program .brown-box p {
	font-weight: 400;
	line-height: 1.3;
}
.ez-start-bridging-program-app .brown-box-section {
    margin-bottom: 5rem;
}
.pso-safety-profile .brown-box p{
	font-weight: 400;
	line-height: 1.3;
}
.ez-start-patient-support-program h5{
	font-size:24px;
	font-weight:700;
}
.psoriatic-arthritis-efficacy .brown-box p{
	line-height: 1.3;
}
.esteem-safety-data-section h2{
	font-weight:400;
	margin-top: 3rem;
}
.footenote-section{
	padding-bottom:6rem;
}
.behcets-disease-safety-profile .footenote-section:nth-child(2){
	padding-bottom:7rem;
}
.index .footenote-section{
	padding-top: 1.5rem;
    padding-bottom: 1rem;
}
.index .footenote-section p{
    font-size: 12px;
}
.pde4-section .footenote-section{
	padding-top:2rem;
	padding-bottom: 6rem;
}
.acr20-16weeks .footenote-section, .pruritus-response-section .footenote-section, .change-in-the-number-of-oral-ulcers-section .footenote-section, .complete-oral-ulcer-response-week12-section .footenote-section, .resolution-of-oral-ulcers-section .footenote-section{
	padding-bottom:2rem;
}
.place-safety-data .footenote-section{
	padding-bottom:1rem;
}
.background-f4f5f6{
	background-color:#F4F5F6;
}
.background-ffffff{
	background-color:#ffffff;
}
.table-block{
	padding:1rem;
}
.table-block h5{
	margin-bottom:1rem;
	color:#003A5D;
	font-weight:700;
	font-size: 17px;
}

.table-block h2{
	margin-bottom:1rem;
	color:#003A5D;
	font-weight:700;
	font-size: 17px;
	margin-bottom: 1rem!important;
}
.custom-table th{
	background-color:#C0D6E3;
	color:#003A5D;
	font-weight: 500;
}
.custom-table, td, th {
	border: 2px solid #003A5D;
    padding: 0.4rem;
    /* width: 6rem; */
    font-size: 16px;
    font-weight: 400;
    color: #6e6e6e;
	text-align: center;
}
.custom-table {
	width: 100%;
	border-collapse: collapse;
}
.custom-table tr:first-child td{
	border-top: 2px solid #ffffff;
	border-left: 2px solid #ffffff;
}

.get-started .custom-table tr:first-child td{
	border-top: 2px solid transparent;
    border-left: 2px solid transparent;
}
.get-started .dose-section h1 {
    margin-bottom: 4rem;
    font-size: 2.25rem;
    color: #003A5D;
    font-weight: 500;
    line-height: 1.2;
}
.get-started .dose-aministration h2 {
    padding-bottom: 0;
    color: #003A5D;
    font-weight: 400;
    font-size: 1.5rem;
}
.get-started .dose-section{
	padding-top:4rem;
	padding-bottom:2rem;
}
.get-started .dose-section p{
}
.get-started .dose-aministration{
	padding-top:4rem;
}
.get-started .dose-aministration h4{
	padding-bottom:2rem;
}
.get-started .footenote-section{
	/* padding-top:6rem; */
}
li{
	color: #003A5D;
}
.content ul.custom{
	padding-inline-start: 25px;
}
.content ul.custom li{
    margin-bottom: 0.5rem;
	line-height: 28px;
}
.second-ul{
	list-style: none;
    text-indent: -15px;
    padding-left: 15px;
}
.otezla-first-only .first-only{
	margin-top:4rem;
}
.otezla-first-only h4{
	padding-bottom: 8rem;
	font-weight: 700;
}
.pde4-section{
    margin-top: 4rem;
}
.pde4-section h5{
	margin-bottom: 4rem;
    color: #003A5D;
    font-size: 24px;
    font-weight: 700;
	margin-top: 5rem;
}

.immune-cell{
	text-align:center;
	margin-bottom:4rem;
}
.pde4-section .brown-box {
	padding-left:2.5rem;
}
.contact-us-section{
	padding-top:4rem;
	padding-bottom: 4rem;
}
.contact-us h4{
	margin-bottom:3rem;
}
.contact-us-section h5{
	color: #003A5D;
	font-size: 24px;
}
.contact-us-section p{
	color: #003A5D;
    margin-top: 1.5rem;
    margin-bottom: 0px;
}
.contact-us-section h2{
	color: #003A5D;
    margin-top: 1.5rem;
    margin-bottom: 0px;
    font-size: 18px;
    font-weight: 700;
}
.contact-us-block p:nth-child(2) {
	margin-top: 0.5rem;
}
.contact-us-section p a{
	color: #003A5D;
}
.contact-us-block{
	padding-bottom:3rem;
}
.isi-ul{
	padding-inline-start:20px;
}
.isi-sub-heading{
	margin-bottom:0rem;
}
.isi-sub-heading li {
	padding-left: 6px;
}
.isi-sub-heading-second{
	padding-top:2.5rem;
	padding-bottom: 1rem;
}
.study-designs, .references{
	margin-top: 3rem;
}
.study-designs h2{
	margin-bottom:0rem;
}
.isi-first-block h2{
	/* padding-top:4rem; */
}
.isi-first-block {
	padding-top: 3.8rem;
}
.isi ul li, .isi p{
	font-size: 16px;
	font-weight: 400;
	line-height: 1.5;
}
.card-block.actual-patient-results-card-block{
    max-width: 530px;
}
.card-blocks.card-blocks-section{
    margin-bottom: 3rem;
}
.page-header{
	margin-top: 4rem;
}
p.see-study-designs{
	color: #B85C00 !important;
    font-size: 18px;
    font-weight: 800;
    margin-bottom: 1.5rem;
}
.psoriasis-efficacy p.see-study-designs, .psa-safety-profile p.see-study-designs, .behcets-disease-efficacy p.see-study-designs, .behcets-disease-safety-profile p.see-study-designs, .pso-safety-profile p.see-study-designs{
    margin-bottom: 1rem;
}
/* .card-block.disease-areas-section-one {
    text-align: left;
    margin: 0;
    min-width: 425px;
} */
ul.diamond{
    position: relative;
    list-style: none;
}
ul.diamond li.list-type-diamond{
    margin-left: -25px;
    position: relative;
}
ul.diamond li.list-type-diamond:after {
    content: '';
    height: .4em;
    width: .4em;
    background: #E88320;
    display: block;
    position: absolute;
    transform: rotate(45deg);
    top: .25em;
    left: -15px;
    margin-top: 5px;
}
.max-width-370{
    max-width: 370px;
}
.text-complete-reimbursement{
	font-size: 13.9px;
    font-weight: 500;
	text-align: center;
}
.acr20-img {
	margin-bottom: 1rem;
    background-color: #fff;
	justify-content: center;
	justify-items: center;
}
.table-bordered-custom th {
	border: 2px solid #000;
	background-color: #C0D5E1;
	padding: 5px 10px;
	color: #00365A;
	font-weight: 600;
	font-size: 18px;
}
.acr20-52weeks .table-bordered-custom th {
	font-weight: 500;
}
.table-bordered-custom{
	width: 90%;
    margin: 0 auto;
}
.acr20-response-at-week52{
	padding-bottom:2rem;
}
.table-bordered-custom th:first-child {
	/* width:45%; */
	text-align:left;
}
.table-bordered-custom td:first-child {
	text-align:left;
}
.table-bordered-custom td {
	border: 2px solid #000;
	background-color: #fff;
	padding: 5px 10px;
	color: #003A5D;
}
.table-bordered-custom td  b{
    font-weight:700;
}
.pasi-75-response-section h2{
	padding-top:4rem;
	padding-bottom: 2rem;
	font-weight: 400;

}
.pasi-75-response-section h1, #mean-pasi-change h1, #pruritus-response h1{
	padding-top:4rem;
	padding-bottom: 2rem;
	font-weight: 400;
	font-size: 2.25rem;
}
.pruritus-response-section h1 {
	padding-bottom: 2rem;
}

.pasi-75-response-section .footenote-section, .mean-pasi-change-section .footenote-section{
	padding-bottom:3rem;
}
.pruritus-response-section h2 {
	padding-bottom: 2rem;
}

.behcets-disease-efficacy .mean-pasi-change-section .footenote-section{
	padding-bottom:3rem;
}
.behcets-disease-efficacy .footenote-section:last-of-type {
    padding-bottom: 7rem;
}
.psoriatic-arthritis-efficacy .table-bordered-custom,  .acr20-response-at-week52 .table-bordered-custom{
    text-align: center;
}
.pasi-75-response-section .see-study-designs, .mean-pasi-change-section .see-study-designs, .pruritus-response-section .see-study-designs{
	padding-top:4rem;
}
.adverse-events{
	padding:2rem 2rem 0.5rem 2rem;
} 
.safety-overview-section .brown-box-section{
	margin-top: 3rem;
    margin-bottom: 6rem;
}
.p-table{
	padding-top:2rem;
	padding-bottom:2rem;
}
.adorn-table tr:first-child td:first-child, .adorn-table tr:nth-child(2) td:first-child {
	border: 0px solid #000;
}
.adorn-table tr td:nth-child(2){
	background-color:#EAEAEA;
}
.adorn-table tr td:nth-child(3){
	background-color:#C0D5E1;
}
.adorn-table tr:first-child td:nth-child(2) {
	background-color:#ffffff;
}
.adverse-reactions-table tr:nth-child(4) td, .adverse-reactions-table tr:nth-child(6) td, .adverse-reactions-table tr:nth-child(16) td, .adverse-reactions-table tr:nth-child(18) td, .adverse-reactions-table tr:nth-child(22) td,  .adverse-reactions-table tr:nth-child(24) td,  .adverse-reactions-table tr:nth-child(28) td {
	background-color:#C0D5E1;
}
.place-safety-data .brown-box-section{
	margin-top: 3rem;
	margin-bottom: 5rem;
}
.p-contact-ez-start{
	display:flex;
	padding-top: 20px;
}
.text-block{
	margin-left:20px;
}
.ez-start-patient-support-program ul.custom {
    padding-inline-start: 0px;
    list-style-position: inside;
}
.ez-start-patient-support-program ul.custom li{
    font-weight:400;
}
.services-section{
	margin-top:2.5rem;
}
.services-section .text-block{
	margin-top:1rem;
}
.services-section .p-contact-ez-start, .medication-delivery-section .p-contact-ez-start{
	margin-top: 0rem;
    padding-top: 10px;
}
.services-section .text-block p{
	font-weight:700;
	margin-bottom:0px;
}
.normal-400{
	font-weight:400 !important;
}
.medication-delivery-section{
	margin-top:3.5rem;
}
.medication-delivery-section .text-block {
    margin-top: 1rem;
}
.ez-start-patient-support-program .brown-box-section {
		margin-bottom: 7rem;
}
#enrolment-forms h2 {
	margin-bottom: 5rem;
}
#enrolment-forms .text-block {
    margin-top: 0.5rem;
}
.program-overview .brown-box-section{
	margin-top:3rem;
	margin-bottom: 3rem;
}
.enrolment-block{
	display:flex;
	margin-bottom: 3rem;
}
.enrolment-forms a{
	color: #774009;
    display: flex;
    align-items: center;
	font-size: 18px;
    font-weight: 500;
}
.enrolment-block .arrow-right{
	margin-left:1rem;
}
.our-exp-block{
	text-align: center;
    max-width: 227px;
    margin: 0 auto;
}
.our-exp-block p{
	font-weight:500;
}
.our-exp-block img{
	margin-bottom:2rem;
}
.margin-bottom-adjust {
	margin-bottom: 1.75rem !important;
}
.our-exp-block img:nth-child(2) {
	margin-bottom: 1.7rem;
}
.padding-bottom-8rem {
	padding-bottom: 8rem !important;
}
.padding-bottom-2rem{
	padding-bottom: 2rem !important;
}
.padding-top-4rem{
	padding-top: 4rem!important;
}
.p-our-exp-block{
	margin-top:4rem;
	margin-bottom:4rem;
}
.behcets-disease-safety-profile .brown-box-section{
	margin-top:2rem;
	margin-bottom:2rem;
}
.bridging-program{
	margin-top:3rem;
	margin-bottom:3rem;
}
.bridging-program-block{
	display: flex;
    align-items: center;
	padding-top: 1rem;
    padding-bottom: 1rem;
}
.bridging-program-block p{
	margin-left:20px;
	margin-bottom: 0;
}
.store{
	display:flex;
	margin-bottom: 1rem;
}
.store img{
	margin-right:2rem;
}

.ez-start-bridging-program-app .footenote-section{
	margin-top: 4rem;
}
.custom-modal .modal-body{
	padding:2rem;
}
.custom-modal ul {
	padding-inline-start: 20px;
}
.custom-modal .btn-default {
	margin-top:1.5rem;
}
.custom-modal ul li, .custom-modal p a {
	color:#003a5d;
}
.patient-support-program-block-text h2 {
    font-weight: 700;
    color: #004165;
    font-size: 18px;
    line-height: 1.45;
    margin-bottom: -27px;
    padding-bottom: 0px;
}
section#program-overview h1{
color: #003A5D;
    margin-bottom: 2.5rem;
    font-size: 2.25rem;
    font-weight: 500;
}
a:-webkit-any-link:focus-visible {
    outline-offset: 0px;
	outline: -webkit-focus-ring-color auto 0px;
}
.btn.focus, .btn:focus {
    outline: 0;
    box-shadow: none;
}
.custom-modal .close {
	position: absolute;
    right: 15px;
    top: 0px;
    font-size: 56px;
    font-weight: normal;
}
.get-started .dose-section h2 {
	margin-bottom: 4rem;
}
#ramq-modal.custom-modal h4{
	margin-bottom:1.5rem;
	font-weight:700;
}
#ramq-modal.custom-modal h5{
	margin-bottom:1.5rem;
	font-size:17px;
}
#ramq-modal.custom-modal ul li, #ramq-modal.custom-modal p{
	font-size: 15px;
	font-weight: 400;
	line-height:1.2;
}
ul.custom-dash{
	list-style-type: none;
}
ul.custom-dash li:before {
  content: '–';
  position: absolute;
  margin-left: -20px;
}
.color-2c2c2c{
	color:#2c2c2c;
}
.actual-patient-results-card-block{
	text-align:center;
}
.acr20-16weeks{
	padding-top:4rem;
}
.mean-pasi-change-section h2{
	padding-top:2rem;
	font-weight: 400;
}
.mean-pasi-change-section .brown-box {
    margin-bottom: 2rem;
}
.pruritus-response-section h2{
	padding-top:4rem;
	font-weight:400;
}
.safety-overview-section{
	padding-top:4rem;
}
.safety-overview-section h2{
	padding-bottom:2rem;
	font-weight: 700;
}
.safety-overview-section h1{
	padding-bottom:2rem;
	font-weight: 700;
	font-size: 2.25rem;
}
.place-safety-data h2{
	padding-bottom:3rem;
	font-weight:400;
}
#place-safety-data h1 {
    padding-bottom: 3rem;
    font-weight: 400;
    font-size: 2.25rem;
    padding-top: 1rem;
}
.place-safety-data{
	padding-bottom:6rem;
}
.change-in-the-number-of-oral-ulcers-section h2 {
    padding-top: 4rem;
	font-weight: 400;
}
.relief-study-response-at-week-12 {
    margin-bottom: 1rem;
    background-color: #fff;
    justify-content: center;
    justify-items: center;
}

.behcets-disease-efficacy .change-in-the-number-para {
    padding-bottom: 2rem;
}

.complete-oral-ulcer-response-week12 {
    margin-top: 4rem;
    padding-bottom: 1rem;
	background-color: #fff;
}
.behcets-disease-efficacy .complete-oral-ulcer-response-week12{
	margin-top: 1rem;
}
.complete-oral-ulcer-response-week12 h5, .resolution-of-oral-ulcers-section h5, .mean-pasi-change-section h5 {
    font-weight:400;
	margin-right: 1.5em;
}
.complete-oral-ulcer-response-week12 h5 b, .resolution-of-oral-ulcers-section h5 b, .mean-pasi-change-section h5 b {
	font-size:32px;
}
.complete-oral-ulcer-response-week12-section {
    /* padding-top: 4rem; */
}
.complete-oral-ulcer-response-week12-section h2, .resolution-of-oral-ulcers-section h2{
    font-weight:400;
}
.behcets-disease-efficacy .brown-box-section-one{
    margin-bottom:1rem;
}
.behcets-disease-efficacy .more-patients{        
    font-size:30px;
    font-weight: 700;
    background-color: transparent;
}
.behcets-disease-efficacy .orange-text{
    color: #C1670F;
    background-color: transparent;
}
.behcets-disease-efficacy .resolution-of-oral-ulcers-section{
    /* padding-top: 4rem; */
}
.two-point-3x-more{
    padding-bottom: 4rem;
}
.program-overview{
	padding-top:4rem;
}
.ez-start-patient-support-program ul{
	padding-inline-start:25px;
}
.enrolment-forms{
	margin-bottom:7rem;
}
.our-experience h2, .behcets-disease-safety-profile h2, .ez-start-bridging-program-app h2{
	padding-top:4rem;
	font-weight: 700;
}
h2.align-top-fix{
	padding-top: 0 !important;
}
.our-experience h1{
	padding-top:4rem;
	font-weight: 700;
}

.ez-start-bridging-program-app h2 {
    padding-bottom: 3rem;
}
.ez-start-bridging-program-app .patient-support-program-block-text h2 {
    padding-bottom: 0px;
}
.our-experience .patient-support-program-block-text h2 {
    margin-bottom: -27px;
}
.behcets-disease-safety-profile .patient-support-program-block-text h2{
	padding-bottom: 0px;
}
.ez-start-bridging-program-app h1 {
    padding-bottom: 0rem;
    padding-top: 4rem;
    font-weight: 700;
    color: #003A5D;
    margin-bottom: 2.5rem;
    font-size: 2.25rem;
}

.ez-start-bridging-program-app .ml-auto h2 {
    padding-bottom: 0rem;
    font-weight: 700;
    font-size: 1.5rem;
    padding-top: 0;
}
.ez-start-bridging-program-app .ml-auto h1 {
    padding-bottom: 0rem;
    font-weight: 700;
    font-size: 1.5rem;

}
.ez-start-bridging-program-app h1 {
    font-weight: 700;
    font-size: 1.5rem;

}

.our-experience h2 {
	margin-bottom: 0.5rem;
}
.our-experience h1 {
	margin-bottom: 0.5rem;
	padding-top: 4rem;
    font-weight: 700;
    color: #003A5D;
    
    font-size: 2.25rem;
}
.our-exp-block h2 {
    margin-top: -4rem;
    font-weight: 700;
    font-size: 40px;
}
.behcets-disease-safety-profile h2 {
    padding-bottom: 2rem;
}
.ez-start-bridging-program-app h4{
	font-weight:700;	
}

.our-experience h1{
	color:#003A5D;
}
.proven-safety-profile-table tr:first-child td:first-child, .proven-safety-profile-table tr:nth-child(2) td:first-child {
	border: 0px solid #000;
}
.proven-safety-profile-table tr td:nth-child(2){
	background-color:#EAEAEA;
}
.proven-safety-profile-table tr td:nth-child(3){
	background-color:#C0D5E1;
}
.proven-safety-profile-table tr:nth-child(4) td, .proven-safety-profile-table tr:nth-child(13) td, .proven-safety-profile-table tr:nth-child(17) td, .proven-safety-profile-table tr:nth-child(21) td, .proven-safety-profile-table tr:nth-child(23) td,  .proven-safety-profile-table tr:nth-child(25) td,  .proven-safety-profile-table tr:nth-child(27) td {
	background-color:#C0D5E1;
}
.proven-safety-profile-table tr:first-child td:nth-child(2) {
	background-color:#ffffff;
}

#welcome-modal .modal-footer{
	border-top: 0px solid #dee2e6;
	justify-content: flex-start;
}
#welcome-modal .modal-footer{
	padding-bottom: 2rem;
}
#welcome-modal .modal-body {
    padding-bottom: 0px;
}
.desktop-only{
	display:block;
}
.mobile-only{
	display:none;
}
.login-mobile-block{
	max-width: 90%;
    margin: 0 auto;
    padding: 2.5rem 1.5rem;
	border-radius: 2%;
	box-shadow: 0px 1px 5px #000000;
}
.secondary-menu.background-f4f5f6{
	border-bottom: 1px solid #cccccc;
}
.study-design-anchor:hover{
	text-decoration:none;
}
.form-block {
    background-color: #E9F6FC;
    margin: 3rem auto;
    padding: 2rem;
	background-image: linear-gradient(#E9F6FC 70%, #fff);
}
.img-footenote{
	font-size:15px;
}
#welcome-modal p, #welcome-modal ul li{
	font-size: 16px;
    font-weight: 400;
    line-height: 1.5;
}
#welcome-modal .btn-default{
	max-width:116px;
	width:116px;
	margin-top: 0;
    margin-left: 21px;
}
.card-block.disease-areas-section-one h5{
	font-weight:700;
	margin-bottom: 0.5rem;
}
.card-block.disease-areas-section-one h2{
	font-weight:700;
	margin-bottom: 0.5rem;
}
.last-item-heading{
	position: absolute;
    top: 0;
    right: 0;
    left: 0;
}
.pasi-score-reduction{
	font-size: 24px;
	font-weight: 700;
	margin-top:1rem;
}
.acr20-16weeks h2, .acr20-52weeks h2{
	font-weight:400;
	margin-bottom: 4rem;
}
.acr20-16weeks h1, .acr20-52weeks h1{
	font-weight:400;
	margin-bottom: 4rem;
	font-size: 2.25rem;
}
.text-color-2c2c2c{
	color:#2c2c2c;
}
.pso-safety-profile.fr .text-color-2c2c2c {
    padding: 0 30px;
}
.pso-safety-profile.fr .text-color-2c2c2c br{
	display: none;
}
.card-block.disease-areas-section-one.left-sec {
    padding-right: 55px;
}
.no-indent{
	text-indent:0px;
	margin-left:0px;
}
.secondary-menu .nav-item:first-child .nav-link{
	text-decoration:underline;
}
.text-decoration {
	text-decoration: underline;
}
#myScrollspy .nav .nav-item a{
	font-size: 16px;
	font-weight: 700;
}
#myScrollspy {
	display: flex;
	align-items: baseline;
	justify-content: center;
}
.no-text-indent {
	text-indent: 0 !important;
}
.fw-500{
	font-weight:500 !important;
}


/*focus visible related*/

a.navbar-brand:focus-visible {
    border: 2px solid #f89a1c;
}
a.nav-link:focus-visible {
    border: 2px solid #f89a1c;
}

a.btn.btn-default.btn-learn-more:focus-visible {
   
    border: 3px solid #f89a1c;
    box-shadow: unset!important;
}

a:focus-visible {
    border: 3px solid #f89a1c;
}
input:focus-visible {
    border: 3px solid #f89a1c!important;
}
.modal-body.scroller:focus-visible {
    border: 3px solid #f89a1c!important;
}
a.btn.btn-default.format-change:focus-visible{
	border: 3px solid #f89a1c!important;
}
.select-selected:focus-visible {
    border: 3px solid #f89a1c!important;
}
.modal-body:focus-visible {
    border: 3px solid #f89a1c!important;
}
p.see-study-designs:focus-visible {
    border: 3px solid #f89a1c!important;
    max-width: 24%;
    padding-top: 1rem!important;   
}

.actual-patient-results .card-blocks.card-blocks-section {
    margin-bottom: 0;
}
.actual-patient-results .footenote-section{
	padding-top: 0;
}

/*banner*/
.floating-banner {
    background-color: #002B42;
}
.banner-section {
    display: flex;
    padding: 2rem;
    max-width: 1170px;
    margin: 0 auto;
    justify-content: space-between;
    align-items: center;
}
.banner-text {
    width: 73%;
}
.banner-text p {
    color: #FFF;
	font-size: 22px;
    line-height: 24px;
}
.banner-button {
    width: 20%;
    display: flex;
    justify-content: center;
}
.banner-button a {
 
	background-color: #B85C00;
    padding: 15px 18px;
    border-radius: 5px;
    color: #FFF;
    text-decoration: none;
    font-weight: 700;
	text-align: center;
}
.banner-button.txt-cen a {
    text-align: center;
}
.banner-text sup.normal-fontweight {
    font-weight: 800;
}
p.banner-note {
    font-size: 14px;
	line-height: 16px;
	margin-bottom: 0;
}



.psoriasis-efficacy .pasi-75-response-section h1, .psoriasis-efficacy #mean-pasi-change h1, .psoriasis-efficacy #pruritus-response h1{
	padding-top: 2rem;
}

@media only screen and (min-width: 576px){
	.p-index-banner{
		padding-right:0px;
		/* order: 2; */
		padding-left: 0px;
	}
	.page-content{
		width:95%;
		margin:0 auto;
	}
	.custom-modal .modal-dialog {
		max-width: 980px;
	}
	.profession-specialty{
		-webkit-appearance: none;
	}
	.stubble:after{
		content: url(/assets-hcp/images/stubble.svg);
		position: absolute;
		top: 0;
		border: 0px;
		left: 15px;
	}
	/*.stubble:before{
		content: url(/assets-hcp/images/stubble.svg);
		position: absolute;
		top: 0;
		border: 0px;
		right: 15px;
	}*/
	.home .card-block h5 {
		min-height: 86px;
	}
	.home .card-block h2 {
		min-height: 86px;
	}
}
@media only screen and (min-width: 768px){
	.home h1{
		font-size:54px;
	}
	.table-bordered-custom td:first-child {
		width:45%;
	}
	.store .scan-img {
		margin-left: 15px;
	}
	.isi-content {
		padding-bottom: 6rem;
	}
	.our-experience .isi-content{
		padding-bottom: 0;
	}
	.pharmacology .footenote-section p {
		padding-left: 8px;
	}
	.disease-areas .card-blocks {
		margin-bottom: 3rem;
	}
	.actual-patient-results .footenote-section{
		padding-bottom: 4rem;
	}
	.disease-areas .footenote-section {
		padding-bottom: 4rem;
	}
	.disease-areas-efficacy-profile .card-blocks {
		margin-top: 2rem;
		margin-bottom: 3rem;
	}
	.disease-areas-efficacy-profile .footenote-section {
		padding-bottom: 4rem;
	}
	.psoriatic-arthritis-efficacy .acr20-16weeks h1, .psoriatic-arthritis-efficacy .acr20-52weeks h1{
		margin-bottom: 2rem;
	}
	.psoriatic-arthritis-efficacy .brown-box-section {
		margin-bottom: 3rem;
	}
	.psoriatic-arthritis-efficacy .footenote-section {
		padding-bottom: 3rem;
	}
	.psoriatic-arthritis-efficacy .acr20-52weeks .footenote-section {
		padding-bottom: 1rem;
	}
	.change-in-the-number-of-oral-ulcers-section h2.patient-experienced {
		padding-top: 1rem;
	}
	.behcets-disease-efficacy .change-in-the-number-of-oral-ulcers-section .brown-box-section{
		margin-bottom: 3rem;
	}
	.behcets-disease-efficacy .footenote-section:last-of-type {
		padding-bottom: 3rem;
	}
	.behcets-disease-efficacy .mean-pasi-change-section .footenote-section {
		padding-bottom: 6rem;
	}
}
@media only screen and (min-width: 768px) and (max-width: 991px){

	.index label {
		font-size:13.9px;
	}
	.navbar-light .navbar-toggler {
        border-color: transparent;
    }
    .form-block {
        padding: 1rem;
    }
    .home .card-block h5 {
        font-size: 21px;
		min-height: 80px;
    }
    .home .card-block h2 {
        font-size: 21px;
		min-height: 80px;
    }
    .disease-areas .btn-default {
        display: inline-block;
    }
    .navbar-nav .dropdown-menu {
        border: none;
    }
	footer .p-amgen-logo-text {
		bottom: auto;
	}
	.text-complete-reimbursement{
		text-indent: 3rem;
	}

}
@media only screen and (min-width: 992px){
	.fr nav .container{
		max-width: 1254px;
	}
	.fr .navbar-expand-lg .navbar-nav .nav-link{
         /*max-width: 126px;  */     
	}
}
@media only screen and (min-width: 1200px){
	.fr .navbar-expand-lg .navbar-nav .nav-link{
         padding-left: 0;
         padding-right: 0;
         max-width: 127px;    
	}
	nav .container{
		max-width:1254px;
	}
	.fr nav .container{
		max-width: 1254px;
	}
	.secondary-menu .container{
		max-width: 1000px;
	}
	.get-started .dose-aministration p.titration-schedule{
		margin-right: -13.7px;
		display: flex;
		align-items: center;
		justify-content: flex-end;
	}
	.get-started .dose-aministration img{
		max-width: fit-content;
	}
	.behcets-disease-efficacy .content.background-f4f5f6 .container, .psoriasis-efficacy  .content.background-f4f5f6 .container, .pso-safety-profile .content.background-f4f5f6 .container,
	.psoriatic-arthritis-efficacy .content.background-f4f5f6 .container, .psa-safety-profile .content.background-f4f5f6 .container, .isi .content.background-f4f5f6 .container{
		max-width: 1441px;
	}
	#myScrollspy{
		justify-content: unset;
	}
	.behcets-disease-efficacy .content .col-lg-9.mx-auto {
		margin-left: 0px!important;
	}
	.image-section-bg {
		width: 75%;
	}
	.fr .image-section-bg{
		width: 80%;
	}
	.pso-safety-profile.fr .image-section-bg {
		width: 85%;
	}
	.behcets-disease-safety-profile.fr .image-section-bg p {
		padding: 0 20px;
	}
	.safety-overview-section .brown-box-section{
		margin-bottom: 2rem;
	}
	.footenote-section.safety-overview-bottom {
		padding-bottom: 1rem;
	}
	.esteem-safety-data-section .brown-box-section {
		margin-bottom: 2rem;
	}
	.place-safety-data .brown-box-section{
		margin-bottom: 2rem;
	}
	.immune-cell{
		text-align: left;
		width: 75%;
		margin-bottom: 2rem;
	}
	.pharmacology .pde4-section .card-blocks {
		width: 75%;
		margin-bottom: 2rem;
	}
}

@media only screen and (min-width: 1024px) and (max-height: 1366px)
    and (-webkit-min-device-pixel-ratio: 1.5) and (hover: none) {
	.navbar-light .navbar-nav .nav-link {
		font-size: 12px;
	}
}

@media only screen and (max-width: 1199px){
	.get-started .dose-aministration p.titration-schedule br {
		display: none;
	}
}

@media only screen and (max-width: 991px){
.fixed-top {
    position: absolute;
    top: 0;
    right: 0;
    left: 0;
    z-index: 1030;
}
.navbar-light .navbar-nav .nav-link.change-language.first-link{
	padding-right: 10px;
}
.language-section a.nav-link.change-language:nth-child(2) {
    padding-left: 10px;
}
.banner-section{
	display: block;
}
.banner-text, .banner-button{
	width: 100%;
}
p.banner-note{
	margin-bottom: 1rem;
}
.footer-part-menus li:lang(en){
    padding-right: 15px;
}
ul.footer-part-menus li a{
	text-decoration: underline;
}
.card-block.disease-areas-section-one.left-sec{
	padding-right: 0;
}
.isi .isi-first-block a {
    word-break: break-all;
}
}

@media only screen and (max-width: 767px){
	.home .card-block {
		margin-bottom: 4rem;
	}
	.warning-msg {
		max-width: 90% !important;
        max-height: 200px !important;
	}
	.isi-content {
		padding-bottom: 4rem;
	}
	.pde4-section .brown-box {
		padding-left: 1rem;
	}
	.card-blocks {
		margin-bottom: 0rem;
	}	
	.actual-patient-results .brown-box {
		padding-left: 1rem;
	}
	.card-blocks.card-blocks-section {
		margin-bottom: 0;
	}
	.pasi-75-response-section h2 {
		padding-top: 3rem;
		padding-bottom: 0rem;
	}
	.pasi-75-response-section h1, #mean-pasi-change h1, #pruritus-response h1 {
		padding-top: 3rem;
		padding-bottom: 0rem;
	}
	.pasi-75-response-section .footenote-section, .mean-pasi-change-section .footenote-section {
		padding-bottom: 0;
	}
	.psoriatic-arthritis-efficacy .brown-box, .pasi-75-response-section .brown-box, .pruritus-response-section .brown-box, .psa-safety-profile .brown-box, .behcets-disease-efficacy .brown-box, .behcets-disease-safety-profile .brown-box, .pso-safety-profile .brown-box, .ez-start-bridging-program-app .brown-box, .ez-start-patient-support-program .brown-box {
		padding-left: 1rem;
		padding-right: 1rem;
	}
	.pasi-75-response-section .see-study-designs, .mean-pasi-change-section .see-study-designs, .pruritus-response-section .see-study-designs {
		padding-top: 2rem;
	}
	.mean-pasi-change-section h2 {
	    padding-bottom: 0;
	}
	.pruritus-response-section .footenote-section:last-of-type {
		padding-bottom: 4rem;
	}
	.safety-overview-section h2 {
		padding-bottom: 0;
		margin-bottom: 1rem;
	}
	.safety-overview-section h1 {
		padding-bottom: 0;
		margin-bottom: 1rem;
		font-size: 1.5rem;
	}
	.safety-overview-section .brown-box-section {
		margin-top: 2rem;
		margin-bottom: 2rem;
	}
	.esteem-safety-data-section h2 {
		margin-top: 1rem;
		margin-bottom: 1rem;
		font-size: 1.5rem;
	}
	.pde4-section .brown-box-section, .change-in-the-number-of-oral-ulcers-section .brown-box-section, .esteem-safety-data-section .brown-box-section {
		margin-bottom: 2rem;
	}
	.disease-areas-efficacy-profile .footenote-section {
		padding-bottom: 2rem;
	}
	.acr20-16weeks h2, .acr20-52weeks h2 {
		margin-bottom: 2rem;
	}
	.acr20-16weeks {
		padding-top: 2rem;
	}
	.place-safety-data h2 {
		padding-bottom: 0rem;
		margin-bottom: 1rem;
	}
	.place-safety-data {
		padding-bottom: 3rem;
	}
	.isi-content {
		padding-bottom: 2rem;
	}
	.otezla-first-only h4 {
		padding-bottom: 3rem;
	}
	.change-in-the-number-of-oral-ulcers-section h2 {
		padding-top: 2rem;
		padding-bottom: 0rem;
	}
	.psoriatic-arthritis-efficacy .footenote-section {
		padding-bottom: 2rem !important;
	}
	.behcets-disease-efficacy .footenote-section:last-of-type {
		padding-bottom: 2rem !important;
	}
	.behcets-disease-safety-profile h2 {
		padding-bottom: 0rem;
		padding-top: 2rem;
	}
	.padding-bottom-8rem {
		padding-bottom: 4rem !important;
	}
	.behcets-disease-safety-profile .brown-box-section {
		margin-top: 1rem;
		margin-bottom: 3rem;
	}
	.pde4-section h5 {
		margin-bottom: 3rem;
		margin-top: 2rem;
	}
	.pde4-section .footenote-section {
		padding-top: 2rem;
		padding-bottom: 4rem;
	}
	.study-designs, .references {
		margin-top: 2rem;
	}
	.complete-oral-ulcer-response-week12-section {
		padding-top: 2rem;
	}
	.psoriatic-arthritis-efficacy .brown-box-section {
		margin-bottom: 3rem;
	}
	
	.actual-patient-results .footenote-section {
		padding-bottom: 4rem;
		padding-top: 0rem;
	}
	.footenote-section {
		padding-bottom: 2rem;
	}
	.brown-box-section {
		margin-bottom: 4rem;
	}
	.word-break {
		word-break: break-all;
	}
	.last-item-heading {
		position: relative;
	}
	.table-bordered-custom.mobile-font-adjust th {
		font-size: 14px;
	}
	.ez-start-patient-support-program .enrolment-block {
		display: block;
	}
	.ez-start-patient-support-program .enrolment-block .img-block{
		float: left;
		margin-right: 25px;
	}
	#enrolment-forms .text-block {
		display: table-cell;
	}
	#welcome-modal .modal-body {
		max-height: 475px;
		overflow-y: scroll;
		margin-right: 0.75rem;
		margin-top: 2rem;
		padding-top: 0px;
	}
	#welcome-modal .btn-default {
		margin-top: 1.5rem;
		width: 100%;
	}
	#welcome-modal .modal-footer {
		border-top: 2px solid #000;
		margin-top: 2rem;
	}
		/* width */
	#welcome-modal .modal-body::-webkit-scrollbar {
	  width: 5px;
	}

	/* Track */
	#welcome-modal .modal-body::-webkit-scrollbar-track {
	  box-shadow: inset 0 0 5px grey; 
	}
	 
	/* Handle */
	#welcome-modal .modal-body::-webkit-scrollbar-thumb {
	  background: #003A5D; 
	}

	/* Handle on hover */
	#welcome-modal .modal-body::-webkit-scrollbar-thumb:hover {
	  background: #003A5D; 
	}
	.desktop-only{
		display:none;
	}
	.mobile-only{
		display:block;
	}
	.index-banner-content {
		display: flex;
		flex-direction: column;
	}
	.apr-image{
		max-width:75%;
		margin:0 auto;
	}
	.index-banner-content h1 {
		margin-left: 1rem;
		text-align: left;
		margin-bottom: 2rem;
		max-width: 100%;
		margin-top: 2rem;
		font-size: 32px;
		margin-right: 1rem;
	}
	p.warning-text{
		margin-bottom:0px;
	}
	.btn-register {
		max-width: 100%;
	}
	.p-login-mobile-block {
		max-width: 90%;
		margin: 0 auto;
		padding: 4rem 0;
		padding-bottom: 6rem;
	}
	select {
		-moz-appearance:none; /* Firefox */
		-webkit-appearance:none; /* Safari and Chrome */
		appearance:none;
		background: transparent;
		background-image: url("data:image/svg+xml;utf8,<svg fill='black' height='24' viewBox='0 0 24 24' width='24' xmlns='http://www.w3.org/2000/svg'><path d='M7 10l5 5 5-5z'/><path d='M0 0h24v24H0z' fill='none'/></svg>");
		background-repeat: no-repeat;
		background-position-x: 100%;
		background-position-y: 5px;
		border: 1px solid #dfdfdf;
		border-radius: 2px;
		margin-right: 2rem;
		padding: 1rem;
		padding-right: 2rem;
	}
	.otezla-mobile-logo{
		margin-bottom: 4rem;
		margin-top: 2rem;
		margin-left: 2rem;
	}
	.secondary-menu ul.nav{
		display: flex;
		flex-direction: column;
		text-align: center;
	}
	h2{
		font-size: 1.5rem;
		margin-bottom: 1.5rem;
	}
	.actual-patient-results h1{
		font-size: 1.5rem!important;
		margin-bottom: 1.5rem;
	}
	.actual-patient-results span.normal-fontweight {
		font-size: 24px!important;
	}
	.ez-start-bridging-program-app h2 {
		padding-bottom: 0rem;
	}
	.get-started .dose-section h2 {
		margin-bottom: 1.5rem;
	}
	.get-started .dose-section {
		padding-bottom: 0rem;
	}
	.adorn-table td, .adorn-table th{
		display: table-cell !important;
	}
	.text-block {
		margin-left: 0rem;
	}
	.p-contact-ez-start .img-block {
		text-align: center;
	}
	.our-exp-block {
		margin-bottom: 5rem;
	}
	#place-safety-data h1{
		padding-bottom: 0rem;
    	margin-bottom: 1rem;
		font-size: 1.5rem;
	}
	section#program-overview h1, #otezla-program h2.otezla-program-heading{
		font-size: 1.5rem;
    	margin-bottom: 1.5rem;
	}
	section#otezla-program h1{
		font-size: 1.5rem;
    	margin-bottom: 1.5rem;
	}
}
@media only screen and (max-width: 575px){
	.p-index-banner{
		padding-right:0px;
		padding-left:0px;
	}
	.card-block {
		margin-bottom: 3rem;
	}
	.custom-table tr > *{
        display: block;
		min-height: 50px;
		border-bottom: 2px solid #003A5D;
    }
	.custom-table, td, th {
		border: 0px solid #003A5D;
	}
    .custom-table tr {
        display: table-cell;
    }
	.custom-table tr td {
		border: 2px solid #003A5D;
		border-left: 0px;
		border-top: 0px;
    }
	.custom-table tr th{
		border: 2px solid #003A5D;
    }
	.custom-table tr:first-child th{
		border-top: 0px solid #ffffff;
    }
	.custom-table.non-home tr:first-child th:first-child{
		border-top: 2px solid #003A5D;
		font-size: 14px;
    }
	.acr20-response-at-week52 .custom-table.non-home tr:first-child th:first-child{
		font-size: 12px;
    }
	.custom-table tr:nth-child(2) th, .custom-table tr:nth-child(3) th{
		border-left: 0px solid #ffffff;
    }
	.table-bordered-custom td {
		font-size: 15px;
		padding: 5px;
	}
	td, th {
		width: 5rem;
		margin: 0 auto;
		align-items: center;
		display: flex !important;
		justify-content: center;
	}
	.custom-table.non-home, td, th {
		width: auto;
	}
	#myScrollspy{
		display:none;
	}
	.table-bordered-custom td:first-child {
		font-size: 12px;
		border-top: 2px solid #003A5D;
	}
}  
@media only screen and (max-width: 320px){
	.table-bordered-custom td {
		font-size: 10px;
	}
} 
.resolution-of-oral-ulcers-section h2 {
	padding-top: 2rem;
}

  .background-ffffff.adverse-events p {
	  margin-bottom: 5px;
  }
  .psa-safety-profile .background-ffffff.adverse-events ul.diamond li.list-type-diamond {
    padding-bottom: 5px;
}


.esteem-safety-data-section .brown-box-section {
	margin-top: 3rem;
}
@media screen and (-ms-high-contrast: active),
  screen and (-ms-high-contrast: none) {
	.home .banner {
		display: block;
	}
	#myScrollspy {
		justify-content: space-between;
	}
	.behcets-disease .banner {
		justify-content: space-between;
	}
	.disease-areas .banner {
		display: block;
	}
	.disease-areas-efficacy-profile .banner {
		display: block;
	}
}

.custom-nav-pills.fixed {
	position: absolute;
	bottom: 0;
}
/* 
@-moz-document url-prefix() {
	
  }  */
.actual-patient-results h2 {
	font-weight: 700;
}
.actual-patient-results h1 {
    font-weight: 700;
     color: #003A5D;
    margin-bottom: 2.5rem;
    font-size: 2.25rem;
}
.actual-patient-results span.normal-fontweight {
    font-size: 36px;
}

.no-wrap {
	white-space: nowrap;
}
.warning-msg {
	position: absolute;
	text-align: center;
	border-radius: 10px;
	font-size: 16px;
	background-color: #ffffff;
	padding: 8px 15px;
	right: 0px;
	left: 0px;
	margin: auto;
	bottom: 95px !important;
	padding-top: 20px;
	padding-bottom: 20px;
	box-shadow: 0px 3px 8px rgb(0 0 0 / 20%);
	z-index: 100;  
	max-width: 430px;
    top: 0;
    bottom: 0;
    max-height: 130px;
	height: fit-content;
  }

  .btn-close.close-warning {
	right: 5px;
    top: 5px;
    width: 25px;
    height: 25px;
    font-size: 10px;
    position: absolute;
    color: #ffffff;
    font-weight: 700;
    line-height: 1.2;
    background: #2fafec 0% 0% no-repeat padding-box;
    border-radius: 50%;
    border: 2px solid #ffffff;
    opacity: 1;
    z-index: 10;
  }
  #myScrollspy .nav-pills li .nav-link {
	  cursor: pointer;
  }
  .select-selected {
    padding: 8px 16px;
    border: 1px solid transparent;
    border-color: transparent transparent rgba(0, 0, 0, 0.1) transparent;
    cursor: pointer;
    background-color: #fff;
    color: #2c2c2c;
    /* font-weight: 600; */
    max-height: 36px;
    border: 1.5px solid #6E6E6E;
    border-radius: .25rem;
    display: flex;
    justify-content: center;
    align-items: center;
    z-index: 100;
    position: relative;
    font-size: 14px;
}
.select-hide {
    display: none;
}
.select-items {
    position: absolute;
    background-color: #fff;
    border-bottom-left-radius: 10px;
    border-bottom-right-radius: 10px;
    top: 65px;
    left: 0;
    right: 0;
    z-index: 99;
    border: 1.5px solid #6E6E6E;
    border-top: 0px;
    text-align: center;
}
.select-items div:first-child {
    padding-top: 20px;
}
.select-items div {
    padding-bottom: 10px;
    padding-top: 10px;
}
.customised-select select {
    display: none;
}
.drpdwn {
    letter-spacing: 0px;
    color: #0063c3;
    opacity: 1;
    width: 100%;
    background: #ffffff 0% 0% no-repeat padding-box;
    border-radius: 10px;
    opacity: 1;
    border: 0;
    border: 2px solid #f2bc17;
    height: 51px;
    font-weight: 700;
    text-align-last: center;
}
#custom-select {
	position: relative;
    max-width: 100%;
    padding: 7px 0 5px 0px;
    border: none;
    background: none;
}
#custom-select::after {
	content: "\25bc";
	position: absolute;
	top: 27px;
	right: 0;
	padding: 0 20px;
	line-height: 52px;
	color: #2c2c2c;
	z-index: 100;
	font-size: 12px;
  }
.input-wrapper {
    position: relative;
    padding-bottom: 0.5rem;
    padding-top: 0.5rem;
}
.warning-text.select {
	padding-top: 35px;
}
.normal-fontweight {
	font-weight: 400;
}
.noindent {
	text-indent: 0 !important;
}
.nowrap {
	white-space: nowrap;
}
ol.bold-numbers {
	margin:0 0 1.5em;
	padding:0;
	counter-reset:item;
}
ol.bold-numbers>li {
	margin:0;
	padding:0 0 0 2em;
	text-indent:-1.5em;
	list-style-type:none;
	counter-increment:item;
}
ol.bold-numbers>li:before {
	display:inline-block;
	width:1.5em;
	padding-right:0.5em;
	font-weight:bold;
	text-align:right;
	content:counter(item) ".";
}
.references li a {
	color: inherit;
	text-decoration: underline;
}
.underline {
	text-decoration: underline;
}
.inherit {
	color: inherit;
}